Actin filament length tunes elasticity of flexibly cross-linked actin networks.
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ABSTRACT:
SUBMITTER: Kasza KE
PROVIDER: S-EPMC2920742 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Actin filament length tunes elasticity of flexibly cross-linked actin networks.
Kasza K E KE Broedersz C P CP Koenderink G H GH Lin Y C YC Messner W W Millman E A EA Nakamura F F Stossel T P TP Mackintosh F C FC Weitz D A DA
Biophysical journal 20100801 4
Networks of the cytoskeletal biopolymer actin cross-linked by the compliant protein filamin form soft gels that stiffen dramatically under shear stress. We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small, rigid cross-links. This behavior is in agreement with a model of rigid filaments connected by multiple flexible linkers. ...[more]
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