Ontology highlight
ABSTRACT:
SUBMITTER: Zou X
PROVIDER: S-EPMC2920744 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Zou Xueqing X Liu Yanxin Y Chen Zhongzhou Z Cárdenas-Jirón Gloria Ines GI Schulten Klaus K
Biophysical journal 20100801 4
Flow-induced shear has been identified as a regulatory driving force in blood clotting. Shear induces beta-hairpin folding of the glycoprotein Ibalpha beta-switch which increases affinity for binding to the von Willebrand factor, a key step in blood clot formation and wound healing. Through 2.1-micros molecular dynamics simulations, we investigate the kinetics of flow-induced beta-hairpin folding. Simulations sampling different flow velocities reveal that under flow, beta-hairpin folding is init ...[more]