Ontology highlight
ABSTRACT:
SUBMITTER: Yu L
PROVIDER: S-EPMC2920749 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Yu Li L McPhee Christina K CK Zheng Lixin L Mardones Gonzalo A GA Rong Yueguang Y Peng Junya J Mi Na N Zhao Ying Y Liu Zhihua Z Wan Fengyi F Hailey Dale W DW Oorschot Viola V Klumperman Judith J Baehrecke Eric H EH Lenardo Michael J MJ
Nature 20100606 7300
Autophagy is an evolutionarily conserved process by which cytoplasmic proteins and organelles are catabolized. During starvation, the protein TOR (target of rapamycin), a nutrient-responsive kinase, is inhibited, and this induces autophagy. In autophagy, double-membrane autophagosomes envelop and sequester intracellular components and then fuse with lysosomes to form autolysosomes, which degrade their contents to regenerate nutrients. Current models of autophagy terminate with the degradation of ...[more]