CD14, a key candidate gene associated with a specific immune response to cockroach.

ABSTRACT:

Background

Sensitization to cockroach allergen is one of the strongest predictors of asthma morbidity, especially among African Americans.

Objective

Our aims were to determine the genomic basis of cockroach sensitization and the specific response to cockroach antigen.

Methods

We investigated the Th1/Th2 cytokine profile of co-cultured plasmacytoid dendritic cells (pDCs) and CD4+ T cells and the 'transcript signature' of the immune response to cockroach antigen using high-throughput expression profiling of co-cultured cells.

Results

We observed significantly elevated levels of IL-13, IL-10, and TNF-alpha, but undetectable levels of IL-12p70 and IFN-alpha, when cultures were exposed to crude cockroach antigen. A significant difference was observed for IL-13 betwe

SUBMITTER: Gao P 

PROVIDER: S-EPMC2920999 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature