A collection of caged compounds for probing roles of local translation in neurobiology.

ABSTRACT: Spatially localized translation plays a vital role in the normal functioning of neuronal systems and is widely believed to be involved in both learning and memory formation. It is of central interest to understand both the phenomenon and molecular mechanisms of local translation using new tools and approaches. Caged compounds can, in principle, be used as tools to investigate local translation since optical activation of bioactive molecules can achieve both spatial and temporal resolution on the micron scale and on the order of seconds or less, respectively. Successful caging of bioactive molecules requires the identification of key functional groups in appropriate molecules and the introduction of a suitable caging moiety. Here we present the design, synthesis and testing of a collection

SUBMITTER: Sadovski O 

PROVIDER: S-EPMC2921030 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature