Ontology highlight
ABSTRACT:
SUBMITTER: Bozdagi O
PROVIDER: S-EPMC2921177 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Bozdagi Ozlem O Wang Xiao-bin XB Nikitczuk Jessica S JS Anderson Tonya R TR Bloss Erik B EB Radice Glenn L GL Zhou Qiang Q Benson Deanna L DL Huntley George W GW
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100701 30
Persistent changes in spine shape are coupled to long-lasting synaptic plasticity in hippocampus. The molecules that coordinate such persistent structural and functional plasticity are unknown. Here, we generated mice in which the cell adhesion molecule N-cadherin was conditionally ablated from postnatal, excitatory synapses in hippocampus. We applied to adult mice of either sex a combination of whole-cell recording, two-photon microscopy, and spine morphometric analysis to show that postnatal a ...[more]