Ontology highlight
ABSTRACT:
SUBMITTER: Soom M
PROVIDER: S-EPMC2921853 | biostudies-literature | 2008 Jul-Aug
REPOSITORIES: biostudies-literature
Soom Malle M Gessner Guido G Heuer Heike H Hoshi Toshinori T Heinemann Stefan H SH
Channels (Austin, Tex.) 20080708 4
Large-conductance Ca(2+)- and voltage-activated K(+) (BK) channels are comprised of four pore-forming -subunits (Slo1), whose mRNA is alternatively spliced in a cell-specific manner. Here we report the first case of a correctly spliced mutually exclusive exon in a mammalian (human and mouse) BK channel; an exon coding for the region from S6 to the RCK1 domain is exchanged for an alternative exon of the same length. The slo1 transcript with this novel exon is present in native brain tissues and i ...[more]