Ontology highlight
ABSTRACT:
SUBMITTER: Goentoro L
PROVIDER: S-EPMC2921914 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Molecular cell 20091201 5
In response to Wnt stimulation, beta-catenin accumulates and activates target genes. Using modeling and experimental analysis, we found that the level of beta-catenin is sensitive to perturbations in the pathway, such that cellular variation would be expected to alter the signaling outcome. One unusual parameter was robust: the fold-change in beta-catenin level (post-Wnt/pre-Wnt). In Xenopus, dorsal-anterior development and target gene expression are robust to perturbations that alter the final ...[more]