Ontology highlight
ABSTRACT:
SUBMITTER: Spangler JB
PROVIDER: S-EPMC2922117 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Spangler Jamie B JB Neil Jason R JR Abramovitch Sivan S Yarden Yosef Y White Forest M FM Lauffenburger Douglas A DA Wittrup K Dane KD
Proceedings of the National Academy of Sciences of the United States of America 20100707 30
Due to its common dysregulation in epithelial-based cancers and extensive characterization of its role in tumor growth, epidermal growth factor receptor (EGFR) is a highly validated target for anticancer therapies. There has been particular interest in the development of monoclonal antibodies (mAbs) targeting EGFR, resulting in two approved mAb-based drugs and several others in clinical trials. It has recently been reported that treatment with combinations of noncompetitive mAbs can induce recep ...[more]