Ontology highlight
ABSTRACT:
SUBMITTER: van Oers JM
PROVIDER: S-EPMC2922181 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
van Oers Johanna M M JM Roa Sergio S Werling Uwe U Liu Yiyong Y Genschel Jochen J Hou Harry H Sellers Rani S RS Modrich Paul P Scharff Matthew D MD Edelmann Winfried W
Proceedings of the National Academy of Sciences of the United States of America 20100712 30
The DNA mismatch repair protein PMS2 was recently found to encode a novel endonuclease activity. To determine the biological functions of this activity in mammals, we generated endonuclease-deficient Pms2E702K knock-in mice. Pms2EK/EK mice displayed increased genomic mutation rates and a strong cancer predisposition. In addition, class switch recombination, but not somatic hypermutation, was impaired in Pms2EK/EK B cells, indicating a specific role in Ig diversity. In contrast to Pms2-/- mice, P ...[more]