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Predictive value of CpG island methylator phenotype for tumor recurrence in hepatitis B virus-associated hepatocellular carcinoma following liver transplantation.

ABSTRACT:

Background

CpG island methylator phenotype (CIMP), in which multiple genes concordantly methylated, has been demonstrated to be associated with progression, recurrence, as well as overall survival in some types of cancer.

Methods

We examined the promoter methylation status of seven genes including P16, CDH1, GSTP1, DAPK, XAF1, SOCS1 and SYK in 65 cases of HCC treated with LT by methylation-specific PCR. CIMP+ was defined as having three or more genes that are concordantly methylated. The relationship between CIMP status and clinicopathological parameters, as well as tumor recurrence was further analyzed.

Results

CIMP+ was more frequent in HCC with AFP > 400 ng/ml than those with AFP ConclusionOur results suggested that CIMP could serve as a new prognostic biomarker to predict the risk of tumor recurrence in HCC after transplantation.

SUBMITTER: Wu LM

PROVIDER: S-EPMC2922195 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Predictive value of CpG island methylator phenotype for tumor recurrence in hepatitis B virus-associated hepatocellular carcinoma following liver transplantation.

Wu Li-Ming LM Zhang Feng F Zhou Lin L Yang Zhe Z Xie Hai-Yang HY Zheng Shu-Sen SS

BMC cancer 20100802

<h4>Background</h4>CpG island methylator phenotype (CIMP), in which multiple genes concordantly methylated, has been demonstrated to be associated with progression, recurrence, as well as overall survival in some types of cancer.<h4>Methods</h4>We examined the promoter methylation status of seven genes including P16, CDH1, GSTP1, DAPK, XAF1, SOCS1 and SYK in 65 cases of HCC treated with LT by methylation-specific PCR. CIMP+ was defined as having three or more genes that are concordantly methylat ...[more]

PMID: 20678188

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