Ontology highlight
ABSTRACT:
SUBMITTER: Yuan H
PROVIDER: S-EPMC2922269 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Yuan Huipin H Fernandes Hugo H Habibovic Pamela P de Boer Jan J Barradas Ana M C AM de Ruiter Ad A Walsh William R WR van Blitterswijk Clemens A CA de Bruijn Joost D JD
Proceedings of the National Academy of Sciences of the United States of America 20100719 31
Biomaterials can be endowed with biologically instructive properties by changing basic parameters such as elasticity and surface texture. However, translation from in vitro proof of concept to clinical application is largely missing. Porous calcium phosphate ceramics are used to treat small bone defects but in general do not induce stem cell differentiation, which is essential for regenerating large bone defects. Here, we prepared calcium phosphate ceramics with varying physicochemical and struc ...[more]