Independent and combined influence of AGTR1 variants and aerobic exercise on oxidative stress in hypertensives.
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ABSTRACT:
SUBMITTER: Fenty-Stewart N
PROVIDER: S-EPMC2922402 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
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Independent and combined influence of AGTR1 variants and aerobic exercise on oxidative stress in hypertensives.
Fenty-Stewart Nicola N Park Joon-Young JY Roth Stephen M SM Hagberg James M JM Basu Samar S Ferrell Robert E RE Brown Michael D MD
Blood pressure 20090101 4
Abstract Angiotensin II (AngII), via the AngII type 1 receptor (AT(1)R), contributes to oxidative stress. Aerobic exercise training (AEXT) reduces the risk of cardiovascular (CV) disease, presumably by reducing the grade of oxidative stress. We investigated the independent and combined influence of the AGTR1 A1166C and -825 T/A polymorphisms on oxidative stress and plasma AngII responses to AEXT in pre- and stage 1 hypertensives. Urinary 8-iso-PGF(2alpha) significantly increased with AEXT (p=0.0 ...[more]
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