Ontology highlight
ABSTRACT:
SUBMITTER: Endeshaw MM
PROVIDER: S-EPMC2922421 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20100708 17
The synthesis and evaluation of 20 dinitroanilines and related compounds against the obligate intracellular parasite Toxoplasma gondii is reported. Using in vitro cultures of parasites in human fibroblasts, we determined that most of these compounds selectively disrupted Toxoplasma microtubules, and several displayed sub-micromolar potency against the parasite. The most potent compound was N(1),N(1)-dipropyl-2,6-dinitro-4-(trifluoromethyl)-1,3-benzenediamine (18b), which displayed an IC(50) valu ...[more]