Ontology highlight
ABSTRACT:
SUBMITTER: Campbell EL
PROVIDER: S-EPMC2922533 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Campbell Eric L EL MacManus Christopher F CF Kominsky Douglas J DJ Keely Simon S Glover Louise E LE Bowers Brittelle E BE Scully Melanie M Bruyninckx Walter J WJ Colgan Sean P SP
Proceedings of the National Academy of Sciences of the United States of America 20100726 32
Resolvin-E1 (RvE1) has been demonstrated to promote inflammatory resolution in numerous disease models. Given the importance of epithelial cells to coordination of mucosal inflammation, we hypothesized that RvE1 elicits an epithelial resolution signature. Initial studies revealed that the RvE1-receptor (ChemR23) is expressed on intestinal epithelial cells (IECs) and that microarray profiling of cells exposed to RvE1 revealed regulation of inflammatory response gene expression. Notably, RvE1 indu ...[more]