Ontology highlight
ABSTRACT:
SUBMITTER: Ganusov VV
PROVIDER: S-EPMC2922917 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Ganusov Vitaly V VV Lukacher Aron E AE Byers Anthony M AM
Virology 20100626 1
Why some viruses establish chronic infections while others do not is poorly understood. One possibility is that the host's immune response is impaired during chronic infections and is unable to clear the virus from the host. In this report, we use a recently proposed framework to estimate the per capita killing efficacy of CD8(+) T cells, specific for the polyoma virus (PyV), which establishes a chronic infection in mice. Surprisingly, the estimated per cell killing efficacy of PyV-specific effe ...[more]