Ontology highlight
ABSTRACT:
SUBMITTER: Warne T
PROVIDER: S-EPMC2923055 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Warne Tony T Serrano-Vega Maria J MJ Baker Jillian G JG Moukhametzianov Rouslan R Edwards Patricia C PC Henderson Richard R Leslie Andrew G W AG Tate Christopher G CG Schertler Gebhard F X GF
Nature 20080625 7203
G-protein-coupled receptors have a major role in transmembrane signalling in most eukaryotes and many are important drug targets. Here we report the 2.7 A resolution crystal structure of a beta(1)-adrenergic receptor in complex with the high-affinity antagonist cyanopindolol. The modified turkey (Meleagris gallopavo) receptor was selected to be in its antagonist conformation and its thermostability improved by earlier limited mutagenesis. The ligand-binding pocket comprises 15 side chains from a ...[more]