Ontology highlight
ABSTRACT:
SUBMITTER: Maki N
PROVIDER: S-EPMC2923362 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Maki Nobuyasu N Suetsugu-Maki Rinako R Sano Shozo S Nakamura Kenta K Nishimura Osamu O Tarui Hiroshi H Del Rio-Tsonis Katia K Ohsumi Keita K Agata Kiyokazu K Tsonis Panagiotis A PA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100511 9
The ability to reprogram in vivo a somatic cell after differentiation is quite limited. One of the most impressive examples of such a process is transdifferentiation of pigmented epithelial cells (PECs) to lens cells during lens regeneration in newts. However, very little is known of the molecular events that allow newt cells to transdifferentiate. Histone B4 is an oocyte-type linker histone that replaces the somatic-type linker histone H1 during reprogramming mediated by somatic cell nuclear tr ...[more]