Ontology highlight
ABSTRACT:
SUBMITTER: Kim N
PROVIDER: S-EPMC2923649 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Nature neuroscience 20071216 1
Motor axons approach muscles that are regionally prespecialized, as acetylcholine receptors are clustered in the central region of muscle before and independently of innervation. This muscle prepattern requires MuSK, a receptor tyrosine kinase that is essential for synapse formation. It is not known how muscle prepatterning is established, and whether motor axons recognize this prepattern. Here we show that expression of Musk is prepatterned in muscle and that early Musk expression in developing ...[more]