Ontology highlight
ABSTRACT:
SUBMITTER: Denmark SE
PROVIDER: S-EPMC2923678 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20100801 33
A general strategy for the construction of macrocyclic lactones containing conjugated Z,Z-1,3-diene subunits is described. The centerpiece of the strategy is a sequential ring-closing metathesis (RCM) that forms an unsaturated siloxane ring, followed by an intramolecular cross-coupling reaction with a pendant alkenyl iodide. A highly modular assembly of the various precursors allowed the preparation of unsaturated macrolactones containing 11-, 12-, 13-, and 14-membered rings. Although the RCM pr ...[more]