Ontology highlight
ABSTRACT:
SUBMITTER: Charles NJ
PROVIDER: S-EPMC2923832 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Charles Nathan J NJ Huebert Robert C RC Lee Sangjin S Adhikari Neeta N Polster Sean S Rider James E JE Braunlin Elizabeth E Mariash Ami A Robledo Maggie M Schuweiler David D Hall Jennifer L JL
Molecular and cellular biochemistry 20100512 1-2
The mitogen activated protein kinase (MAPK) signaling pathway regulates multiple events leading to heart failure including ventricular remodeling, contractility, hypertrophy, apoptosis, and fibrosis. The regulation of conserved intrinsic inhibitors of this pathway is poorly understood. We recently identified an up-regulation of Sprouty1 (Spry1) in a targeted approach for novel inhibitors of the MAPK signaling pathway in failing human hearts following reverse remodeling. The goal of this study wa ...[more]