The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.
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ABSTRACT:
SUBMITTER: Krishnakumar R
PROVIDER: S-EPMC2923840 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.
Krishnakumar Raga R Kraus W Lee WL
Molecular cell 20100701 1
The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity. ...[more]
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