Ontology highlight
ABSTRACT:
SUBMITTER: Jincho Y
PROVIDER: S-EPMC2924067 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Jincho Yuko Y Araki Ryoko R Hoki Yuko Y Tamura Chihiro C Nakamura Miki M Ando Shunsuke S Kasama Yasuji Y Abe Masumi M
The Journal of biological chemistry 20100616 34
Although the induction of genome integration-free induced pluripotent stem cells (iPSCs) has been reported, c-Myc was still required for the efficient generation of these cells. Herein, we report mouse strain-dependent differences in the c-Myc dependence for iPSC generation and the successful generation of genome integration-free iPSCs without c-Myc transduction using C57BL/6 mouse embryonic fibroblasts. We performed 49 independent experiments and obtained a total of 24 iPSC clones, including 18 ...[more]