Ontology highlight
ABSTRACT:
SUBMITTER: Bendor J
PROVIDER: S-EPMC2924642 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
The EMBO journal 20100727 16
Of the five mammalian muscarinic acetylcholine (ACh) receptors, M(5) is the only subtype expressed in midbrain dopaminergic neurons, where it functions to potentiate dopamine release. We have identified a direct physical interaction between M(5) and the AP-3 adaptor complex regulator AGAP1. This interaction was specific with regard to muscarinic receptor (MR) and AGAP subtypes, and mediated the binding of AP-3 to M(5). Interaction with AGAP1 and activity of AP-3 were required for the endocytic r ...[more]