Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura T
PROVIDER: S-EPMC2924818 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Nakamura Tomohiro T Wang Lei L Wong Catherine C L CC Scott Fiona L FL Eckelman Brendan P BP Han Xuemei X Tzitzilonis Christos C Meng Fanjun F Gu Zezong Z Holland Emily A EA Clemente Arjay T AT Okamoto Shu-ichi S Salvesen Guy S GS Riek Roland R Yates John R JR Lipton Stuart A SA
Molecular cell 20100701 2
X-linked inhibitor of apoptosis (XIAP) is a potent antagonist of caspase apoptotic activity. XIAP also functions as an E3 ubiquitin ligase, targeting caspases for degradation. However, molecular pathways controlling XIAP activities remain unclear. Here, we report that nitric oxide (NO) reacts with XIAP by S-nitrosylating its RING domain (forming SNO-XIAP), thereby inhibiting E3 ligase and antiapoptotic activity. NO-mediated neurotoxicity and caspase activation have been linked to several neurode ...[more]