Ontology highlight
ABSTRACT:
SUBMITTER: Attur M
PROVIDER: S-EPMC2925146 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Annals of the rheumatic diseases 20091123 5
<h4>Background</h4>A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs.<h4>Objective</h4>To determine whether inflammatory genetic markers could stratify patients with knee OA into high and low risk for destructive disease.<h4>Methods</h4>Genotype associations with knee OA severity were assessed in two Caucasian populations. Fifteen single nucleotide polymorphisms (SNPs) in six inflammatory genes were evaluated ...[more]