Microdynamics and criticality of adaptive regulatory networks.
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ABSTRACT:
SUBMITTER: MacArthur BD
PROVIDER: S-EPMC2925242 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Microdynamics and criticality of adaptive regulatory networks.
MacArthur Ben D BD Sánchez-García Rubén J RJ Ma'ayan Avi A
Physical review letters 20100419 16
We present a model of adaptive regulatory networks consisting of a simple biologically motivated rewiring procedure coupled to an elementary stability criterion. The resulting networks exhibit a characteristic stationary heavy-tailed degree distribution, show complex structural microdynamics, and self-organize to a dynamically critical state. We show analytically that the observed criticality results from the formation and breaking of transient feedback loops during the adaptive process. ...[more]
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