Ontology highlight
ABSTRACT:
SUBMITTER: Brettschneider C
PROVIDER: S-EPMC2925524 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Brettschneider Christian C Rose Rebecca J RJ Hertel Stefanie S Axmann Ilka M IM Heck Albert J R AJ Kollmann Markus M
Molecular systems biology 20100701
The circadian rhythm of the cyanobacterium Synechococcus elongatus is controlled by three proteins, KaiA, KaiB, and KaiC. In a test tube, these proteins form complexes of various stoichiometry and the average phosphorylation level of KaiC exhibits robust circadian oscillations in the presence of ATP. Using mathematical modeling, we were able to reproduce quantitatively the experimentally observed phosphorylation dynamics of the KaiABC clockwork in vitro. We thereby identified a highly non-linear ...[more]