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The secreted proteome profile of developing Dictyostelium discoideum cells.

ABSTRACT: Dictyostelium discoideum is a unicellular eukaryote that, when starved, aggregates to form multicellular structures. In this report, we identified the proteins secreted by developing Dictyostelium cells using MS-based proteomics. A total of 349 different secreted proteins were identified, indicating that at least 2.6% of the 13 600 predicted proteins in the Dictyostelium genome are secreted. Gene ontology analysis suggests that many of the secreted proteins are involved in protein and carbohydrate metabolism, and proteolysis.

SUBMITTER: Bakthavatsalam D

PROVIDER: S-EPMC2926150 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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The secreted proteome profile of developing Dictyostelium discoideum cells.

Bakthavatsalam Deenadayalan D Gomer Richard H RH

Proteomics 20100701 13

Dictyostelium discoideum is a unicellular eukaryote that, when starved, aggregates to form multicellular structures. In this report, we identified the proteins secreted by developing Dictyostelium cells using MS-based proteomics. A total of 349 different secreted proteins were identified, indicating that at least 2.6% of the 13 600 predicted proteins in the Dictyostelium genome are secreted. Gene ontology analysis suggests that many of the secreted proteins are involved in protein and carbohydra ...[more]

PMID: 20422638

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