Ontology highlight
ABSTRACT:
SUBMITTER: Culler SJ
PROVIDER: S-EPMC2926609 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Nucleic acids research 20100412 15
Despite the critical role of pre-mRNA splicing in generating proteomic diversity and regulating gene expression, the sequence composition and function of intronic splicing regulatory elements (ISREs) have not been well elucidated. Here, we employed a high-throughput in vivo Screening PLatform for Intronic Control Elements (SPLICE) to identify 125 unique ISRE sequences from a random nucleotide library in human cells. Bioinformatic analyses reveal consensus motifs that resemble splicing regulatory ...[more]