Ontology highlight
ABSTRACT:
SUBMITTER: Sasai N
PROVIDER: S-EPMC2926618 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Sasai Nobuhiro N Nakao Mitsuyoshi M Defossez Pierre-Antoine PA
Nucleic acids research 20100419 15
DNA methylation is an essential epigenetic mark. Three classes of mammalian proteins recognize methylated DNA: MBD proteins, SRA proteins and the zinc-finger proteins Kaiso, ZBTB4 and ZBTB38. The last three proteins can bind either methylated DNA or unmethylated consensus sequences; how this is achieved is largely unclear. Here, we report that the human zinc-finger proteins Kaiso, ZBTB4 and ZBTB38 can bind methylated DNA in a sequence-specific manner, and that they may use a mode of binding comm ...[more]