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Sequence-specific recognition of methylated DNA by human zinc-finger proteins.


ABSTRACT: DNA methylation is an essential epigenetic mark. Three classes of mammalian proteins recognize methylated DNA: MBD proteins, SRA proteins and the zinc-finger proteins Kaiso, ZBTB4 and ZBTB38. The last three proteins can bind either methylated DNA or unmethylated consensus sequences; how this is achieved is largely unclear. Here, we report that the human zinc-finger proteins Kaiso, ZBTB4 and ZBTB38 can bind methylated DNA in a sequence-specific manner, and that they may use a mode of binding common to other zinc-finger proteins. This suggests that many other sequence-specific methyl binding proteins may exist.

SUBMITTER: Sasai N 

PROVIDER: S-EPMC2926618 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Sequence-specific recognition of methylated DNA by human zinc-finger proteins.

Sasai Nobuhiro N   Nakao Mitsuyoshi M   Defossez Pierre-Antoine PA  

Nucleic acids research 20100419 15


DNA methylation is an essential epigenetic mark. Three classes of mammalian proteins recognize methylated DNA: MBD proteins, SRA proteins and the zinc-finger proteins Kaiso, ZBTB4 and ZBTB38. The last three proteins can bind either methylated DNA or unmethylated consensus sequences; how this is achieved is largely unclear. Here, we report that the human zinc-finger proteins Kaiso, ZBTB4 and ZBTB38 can bind methylated DNA in a sequence-specific manner, and that they may use a mode of binding comm  ...[more]

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