Ontology highlight
ABSTRACT:
SUBMITTER: Lane DP
PROVIDER: S-EPMC2926755 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Lane David P DP Cheok Chit Fang CF Lain Sonia S
Cold Spring Harbor perspectives in biology 20100512 9
Inactivation of p53 functions is an almost universal feature of human cancer cells. This has spurred a tremendous effort to develop p53 based cancer therapies. Gene therapy using wild-type p53, delivered by adenovirus vectors, is now in widespread use in China. Other biologic approaches include the development of oncolytic viruses designed to replicate and kill only p53 defective cells and also the development of siRNA and antisense RNA's that activate p53 by inhibiting the function of the negat ...[more]