Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC2927118 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Xu Jing J Caro-Diaz Eduardo J E EJ Theodorakis Emmanuel A EA
Organic letters 20100801 16
An enantioselective formal synthesis of (-)-englerin A (1) is reported. Key to the strategy is a Rh-catalyzed [4 + 3] cycloaddition reaction between furan 10 and diazo ester 11 that, following an intramolecular aldol condensation, produces the tricyclic scaffold of englerin. This strategy also provides a rapid, efficient, and stereoselective access to the biologically significant core motif of the guaiane sesquiterpenes. ...[more]