Irinotecan pharmacogenomics.
Ontology highlight
ABSTRACT:
SUBMITTER: Marsh S
PROVIDER: S-EPMC2927346 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
Irinotecan is a camptothecin analog used as an anticancer drug. Severe, potentially life-threatening toxicities can occur from irinotecan treatment. Although multiple genes may play a role in irinotecan activity, the majority of evidence to date suggests that variation in expression of UGT1A1 caused by a common promoter polymorphism (UGT1A1*28) is strongly associated with toxicity; however, this link is dose dependent. Variations in other pharmacokinetic genes, particularly the transporter ABCC2 ...[more]
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