Ontology highlight
ABSTRACT:
SUBMITTER: Tikhmyanova N
PROVIDER: S-EPMC2927436 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Tikhmyanova Nadezhda N Tulin Alexei V AV Roegiers Fabrice F Golemis Erica A EA
PloS one 20100824 8
Mammalian Cas proteins regulate cell migration, division and survival, and are often deregulated in cancer. However, the presence of four paralogous Cas family members in mammals (BCAR1/p130Cas, EFS/Sin1, NEDD9/HEF1/Cas-L, and CASS4/HEPL) has limited their analysis in development. We deleted the single Drosophila Cas gene, Dcas, to probe the developmental function of Dcas. Loss of Dcas had limited effect on embryonal development. However, we found that Dcas is an important modulator of the sever ...[more]