Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto M
PROVIDER: S-EPMC2927672 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Yamamoto Mai M Morita Ryoko R Mizoguchi Takamasa T Matsuo Hiromi H Isoda Miho M Ishitani Tohru T Chitnis Ajay B AB Matsumoto Kunihiro K Crump J Gage JG Hozumi Katsuto K Yonemura Shigenobu S Kawakami Koichi K Itoh Motoyuki M
Development (Cambridge, England) 20100623 15
In the developing embryo, cell-cell signalling is necessary for tissue patterning and structural organization. During midline development, the notochord plays roles in the patterning of its surrounding tissues while forming the axial structure; however, how these patterning and structural roles are coordinated remains elusive. Here, we identify a mechanism by which Notch signalling regulates the patterning activities and structural integrity of the notochord. We found that Mind bomb (Mib) ubiqui ...[more]