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Predictive modeling of lung motion over the entire respiratory cycle using measured pressure-volume data, 4DCT images, and finite-element analysis.

ABSTRACT: Predicting complex patterns of respiration can benefit the management of the respiratory motion for radiation therapy of lung cancer. The purpose of the present work was to develop a patient-specific, physiologically relevant respiratory motion model which is capable of predicting lung tumor motion over a complete normal breathing cycle.Currently employed techniques for generating the lung geometry from four-dimensional computed tomography data tend to lose details of mesh topology due to excessive surface smoothening. Some of the existing models apply displacement boundary conditions instead of the intrapleural pressure as the actual motive force for respiration, while others ignore the nonlinearity of lung tissues or the mechanics of pleural sliding. An intermediate nonuniform rational basis spline surface representation is used to avoid multiple geometric smoothing procedures used in the computational mesh preparation. Measured chest pressure-volume relationships are used to simulate pressure loading on the surface of the model for a given lung volume, as in actual breathing. A hyperelastic model, developed from experimental observations, has been used to model the lung tissue material. Pleural sliding on the inside of the ribcage has also been considered.The finite-element model has been validated using landmarks from four patient CT data sets over 34 breathing phases. The average differences of end-inspiration in position between the landmarks and those predicted by the model are observed to be 0.450 +/- 0.330 cm for Patient P1, 0.387 +/- 0.169 cm for Patient P2, 0.319 +/- 0.186 cm for Patient P3, and 0.204 +/- 0.102 cm for Patient P4 in the magnitude of error vector, respectively. The average errors of prediction at landmarks over multiple breathing phases in superior-inferior direction are less than 3 mm.The prediction capability of pressure-volume curve driven nonlinear finite-element model is consistent over the entire breathing cycle. The biomechanical parameters in the model are physiologically measurable, so that the results can be extended to other patients and additional neighboring organs affected by respiratory motion.

SUBMITTER: Eom J

PROVIDER: S-EPMC2927691 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Predictive modeling of lung motion over the entire respiratory cycle using measured pressure-volume data, 4DCT images, and finite-element analysis.

Eom Jaesung J Xu Xie George XG De Suvranu S Shi Chengyu C

Medical physics 20100801 8

<h4>Purpose</h4>Predicting complex patterns of respiration can benefit the management of the respiratory motion for radiation therapy of lung cancer. The purpose of the present work was to develop a patient-specific, physiologically relevant respiratory motion model which is capable of predicting lung tumor motion over a complete normal breathing cycle.<h4>Methods</h4>Currently employed techniques for generating the lung geometry from four-dimensional computed tomography data tend to lose detail ...[more]

PMID: 20879598

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Project description:BackgroundIn adults, a single pre-treatment four-dimensional CT (4D-CT) acquisition is often used to account for respiratory-induced target motion during radiotherapy. However, studies have indicated that a 4D-CT is not always representative for respiratory motion. Our aim was to investigate whether respiratory-induced diaphragm motion in children on a single pre-treatment 4DCT can accurately predict respiratory-induced diaphragm motion as observed on cone beam CTs (CBCTs).MethodsTwelve patients (mean age 14.5 yrs.; range 8.6-17.9 yrs) were retrospectively included based on visibility of the diaphragm on abdominal or thoracic imaging data acquired during free breathing. A 4DCT for planning purposes and daily/weekly CBCTs (total 125; range 4-29 per patient) acquired prior to dose delivery were available. The amplitude, corresponding to the difference in position of the diaphragm in cranial-caudal direction in end-inspiration and end-expiration phases, was extracted from the 4DCT (A4DCT). The amplitude in CBCTs (ACBCT) was defined as displacement between averaged in- and expiration diaphragm positions on corresponding projection images, and the distribution of ACBCT was compared to A4DCT (one-sample t-test, significance level p?< 0.05).ResultsOver all patients, the mean A4DCT was 10.4 mm and the mean ACBCT 11.6 mm. For 9/12 patients, A4DCT differed significantly (p <?0.05) from ACBCT. Differences >?3 mm were found in 69/125 CBCTs (55%), with A4DCT mostly underestimating ACBCT. For 7/12 patients, diaphragm positions differed significantly from the baseline position.ConclusionRespiratory-induced diaphragm motion determined on 4DCT does not accurately predict the daily respiratory-induced diaphragm motion observed on CBCTs, as the amplitude and baseline position differed statistically significantly in the majority of patients. Regular monitoring of respiratory motion during the treatment course using CBCTs could yield a higher accuracy when a daily adaptation to the actual breathing amplitude takes place.

Project description:BackgroundThe presence of left ventricular (LV) wall motion abnormalities (WMA) is an independent indicator of adverse cardiovascular events in patients with cardiovascular diseases. We develop and evaluate the ability to detect cardiac wall motion abnormalities (WMA) from dynamic volume renderings (VR) of clinical 4D computed tomography (CT) angiograms using a deep learning (DL) framework.MethodsThree hundred forty-three ECG-gated cardiac 4DCT studies (age: 61 ± 15, 60.1% male) were retrospectively evaluated. Volume-rendering videos of the LV blood pool were generated from 6 different perspectives (i.e., six views corresponding to every 60-degree rotation around the LV long axis); resulting in 2058 unique videos. Ground-truth WMA classification for each video was performed by evaluating the extent of impaired regional shortening visible (measured in the original 4DCT data). DL classification of each video for the presence of WMA was performed by first extracting image features frame-by-frame using a pre-trained Inception network and then evaluating the set of features using a long short-term memory network. Data were split into 60% for 5-fold cross-validation and 40% for testing.ResultsVolume rendering videos represent ~800-fold data compression of the 4DCT volumes. Per-video DL classification performance was high for both cross-validation (accuracy = 93.1%, sensitivity = 90.0% and specificity = 95.1%, κ: 0.86) and testing (90.9, 90.2, and 91.4% respectively, κ: 0.81). Per-study performance was also high (cross-validation: 93.7, 93.5, 93.8%, κ: 0.87; testing: 93.5, 91.9, 94.7%, κ: 0.87). By re-binning per-video results into the 6 regional views of the LV we showed DL was accurate (mean accuracy = 93.1 and 90.9% for cross-validation and testing cohort, respectively) for every region. DL classification strongly agreed (accuracy = 91.0%, κ: 0.81) with expert visual assessment.ConclusionsDynamic volume rendering of the LV blood pool combined with DL classification can accurately detect regional WMA from cardiac CT.

Project description:In this paper, the seismic assessments of two footbridges, i.e., a single-span steel frame footbridge and a three-span cable-stayed structure, to the spatial variation of earthquake ground motion (SVEGM) are presented. A model of nonuniform kinematic excitation was used for the dynamic analyses of the footbridges. The influence of SVEGM on the dynamic performance of structures was assessed on both experimental and numerical ways. The comprehensive tests were planned and carried out on both structures. The investigation was divided into two parts: in situ experiment and numerical analyses. The first experimental part served for the validation of both the finite element (FE) modal models of structures and the theoretical model of nonuniform excitation as well as the appropriateness of the FE procedures used for dynamic analyses. First, the modal properties were validated. The differences between the numerical and the experimental natural frequencies, obtained using the operational modal analysis, were less than 10%. The comparison of the experimental and numerical mode shapes also proved a good agreement since the modal assurance criterion values were satisfactory for both structures. Secondly, nonuniform kinematic excitation was experimentally imposed using vibroseis tests. The apparent wave velocities, evaluated from the cross-correlation functions of the acceleration-time histories registered at two consecutive structures supports, equaled 203 and 214 m/s for both structures, respectively. Also, the coherence functions proved the similarity of the signals, especially for the frequency range 5 to 15 Hz. Then, artificial kinematic excitation was generated on the basis of the adopted model of nonuniform excitation. The obtained power spectral density functions of acceleration-time histories registered at all supports as well as the cross-spectral density functions between registered and artificial acceleration-time histories confirmed the strong similarity of the measured and artificial signals. Finally, the experimental and numerical assessments of the footbridges performance under the known dynamic excitation generated by the vibroseis were carried out. The FE models and procedures were positively validated by linking full-scale tests and numerical calculations. In the numerical part of the research, seismic analyses of the footbridges were conducted. The dynamic responses of structures to a representative seismic shock were calculated. Both the uniform and nonuniform models of excitation were applied to demonstrate and quantify the influence of SVEGM on the seismic assessment of footbridges. It occurred that SVEGM may generate non-conservative results in comparison with classic uniform seismic excitation. For the stiff steel frame footbridge the maximum dynamic response was obtained for the model of nonuniform excitation with the lowest wave velocity. Especially zones located closely to stiff frame nodes were significantly more disturbed. For the flexible cable-stayed footbridge, in case of nonuniform excitation, the dynamic response was enhanced only at the points located in the extreme spans and in the midspan closely to the pillars.

Dataset Information

Predictive modeling of lung motion over the entire respiratory cycle using measured pressure-volume data, 4DCT images, and finite-element analysis.

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Predictive modeling of lung motion over the entire respiratory cycle using measured pressure-volume data, 4DCT images, and finite-element analysis.

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