Ontology highlight
ABSTRACT:
SUBMITTER: Heard M
PROVIDER: S-EPMC2927863 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Genesis (New York, N.Y. : 2000) 20100801 8
NR4A nuclear receptors are a diverse group of orphan nuclear receptors with critical roles in regulating cell proliferation and cell differentiation. The ortholog of the NR4A nuclear receptor in Caenorhabditis elegans, NHR-6, also has a role in cell proliferation and cell differentiation during organogenesis of the spermatheca. Here we show that NHR-6 is able to bind the canonical NR4A monomer response element and can transactivate from this site in mammalian HEK293 cells. Using a functional GFP ...[more]