Ontology highlight
ABSTRACT:
SUBMITTER: Chantarasriwong O
PROVIDER: S-EPMC2927871 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Chantarasriwong Oraphin O Cho Woo Cheal WC Batova Ayse A Chavasiri Warinthorn W Moore Curtis C Rheingold Arnold L AL Theodorakis Emmanuel A EA
Organic & biomolecular chemistry 20090924 23
The combination of unique structure and potent bioactivity exhibited by several family members of the caged Garcinia xanthones, led us to evaluate their pharmacophore. We have developed a Pd(0)-catalyzed method for the reverse prenylation of catechols that, together with a Claisen/Diels-Alder reaction cascade, provides rapid and efficient access to various caged analogues. Evaluation of the growth inhibitory activity of these compounds leads to the conclusion that the intact ABC ring system cont ...[more]