Ontology highlight
ABSTRACT:
SUBMITTER: Palde PB
PROVIDER: S-EPMC2928052 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Palde Prakash B PB Ofori Leslie O LO Gareiss Peter C PC Lerea Jaclyn J Miller Benjamin L BL
Journal of medicinal chemistry 20100801 16
Production of the Gag-Pol polyprotein in human immunodeficiency virus (HIV) requires a -1 ribosomal frameshift, which is directed by a highly conserved RNA stem-loop. Building on our discovery of a set of disulfide-containing peptides that bind this RNA, we describe medicinal chemistry efforts designed to begin to understand the structure-activity relationships and RNA sequence-selectivity relationships associated with these compounds. Additionally, we have prepared analogues incorporating an ol ...[more]