Ontology highlight
ABSTRACT:
SUBMITTER: Qualls JE
PROVIDER: S-EPMC2928148 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Qualls Joseph E JE Neale Geoffrey G Smith Amber M AM Koo Mi-Sun MS DeFreitas Ashley A AA Zhang Huiyuan H Kaplan Gilla G Watowich Stephanie S SS Murray Peter J PJ
Science signaling 20100817 135
Nitric oxide (NO) produced by macrophages is toxic to host tissues and invading pathogens, and its regulation is essential to suppress host cytotoxicity. Macrophage arginase 1 (Arg1) competes with NO synthases for arginine, a substrate common to both types of enzymes, to inhibit NO production. Two signal transduction pathways control the production of Arg1 in macrophages: One pathway dependent on the Toll-like receptor adaptor protein myeloid differentiation marker 88 (MyD88) induces the express ...[more]