Dataset Information

Cognitive function in type 1 diabetic adults with early exposure to severe hypoglycemia: a 16-year follow-up study.

ABSTRACT:

Objective

We assessed adulthood cognition in relation to early exposure to severe hypoglycemia (SH).

Research design and methods

Sixteen years subsequent to a study of cognitive function in 28 diabetic children and 28 matched control subjects, we reexamined the same subjects with a 96% participation rate. Diabetic subjects were classified as with (n = 9) or without (n = 18) early (ResultsOverall, cognitive scores were 0.9 SDs lower in subjects with early SH compared with subjects without early SH (P = 0.003). The two diabetic groups particularly differed with respect to problem solving, verbal function, and psychomotor efficiency. Earlier age at first incident of SH was associated with poorer cognition (P for trend = 0.001).

Conclusions

The findings suggest that early exposure to SH may have lasting and clinically relevant effects on cognition.

SUBMITTER: Asvold BO

PROVIDER: S-EPMC2928338 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Publications

Cognitive function in type 1 diabetic adults with early exposure to severe hypoglycemia: a 16-year follow-up study.

Asvold Bjørn O BO Sand Trond T Hestad Knut K Bjørgaas Marit R MR

Diabetes care 20100901 9

<h4>Objective</h4>We assessed adulthood cognition in relation to early exposure to severe hypoglycemia (SH).<h4>Research design and methods</h4>Sixteen years subsequent to a study of cognitive function in 28 diabetic children and 28 matched control subjects, we reexamined the same subjects with a 96% participation rate. Diabetic subjects were classified as with (n = 9) or without (n = 18) early (<or=10 years of age) SH, which was defined as convulsions or loss of consciousness.<h4>Results</h4>Ov ...[more]

PMID: 20805272

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Project description:ObjectiveThe surgical option could represent a valid alternative to medical therapy in some diabetic patients. However, no data are available on long-term effects of metabolic surgery on diabetic complications. We aimed to determine whether patients with newly diagnosed type 2 diabetes who underwent bilio-pancreatic diversion (BPD) had less micro- and macrovascular complications than those who received conventional therapy.Research design and methodsThis was an unblinded, case-controlled trial with 10-years' follow-up, conducted from July 1998 through October 2009 at the Day Hospital of Metabolic Diseases, Catholic University, Rome, Italy. A consecutive sample of 110 obese patients (BMI >35 kg/m(2)) with newly diagnosed type 2 diabetes was enrolled. The study was completed by 50 subjects. The main outcome measure was long-term effects (10 years) of BPD versus those associated with conventional therapy on microvascular outcome, micro- and macroalbuminuria, and glomerular filtration rate (GFR). Secondary measures included macrovascular outcomes, type 2 diabetes remission, glycated hemoglobin, and hyperlipidemia.ResultsTen-year GFR variation was -45.7 ± 18.8% in the medical arm and 13.6 ± 24.5% in the surgical arm (P < 0.001). Ten-year hypercreatininemia prevalence was 39.3% in control subjects and 9% in BPD subjects (P = 0.001). After 10 years, all BPD subjects recovered from microalbuminuria, whereas microalbuminuria appeared or progressed to macroalbuminuria in control subjects. Three myocardial infarctions, determined by electrocardiogram, and one stroke occurred in control subjects. After the 10-year follow-up, coronary heart disease (CHD) probability was 0.22 ± 0.10 and 0.05 ± 0.04 in the medical and surgical groups, respectively (P < 0.001). Remission from type 2 diabetes was observed in all patients within 1 year of surgery. Surgical and medical subjects had lost 34.60 ± 10.25 and 0.38 ± 6.10% of initial weight at the 10-year follow-up (P < 0.001).ConclusionsRenal and cardiovascular complications were dramatically reduced in the surgical arm, indicating long-term benefits of BPD on diabetic complications, at least in the case of morbid obesity with decompensated type 2 diabetes.

Dataset Information

Cognitive function in type 1 diabetic adults with early exposure to severe hypoglycemia: a 16-year follow-up study.

Objective

Research design and methods

Conclusions

Publications

Cognitive function in type 1 diabetic adults with early exposure to severe hypoglycemia: a 16-year follow-up study.

Similar Datasets

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