Ontology highlight
ABSTRACT:
SUBMITTER: Ewing AD
PROVIDER: S-EPMC2928504 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Ewing Adam D AD Kazazian Haig H HH
Genome research 20100520 9
Using high-throughput sequencing, we devised a technique to determine the insertion sites of virtually all members of the human-specific L1 retrotransposon family in any human genome. Using diagnostic nucleotides, we were able to locate the approximately 800 L1Hs copies corresponding specifically to the pre-Ta, Ta-0, and Ta-1 L1Hs subfamilies, with over 90% of sequenced reads corresponding to human-specific elements. We find that any two individual genomes differ at an average of 285 sites with ...[more]