Subtype identification and functional characterization of ryanodine receptors in rat cerebral artery myocytes.

ABSTRACT: Ryanodine receptors (RyRs) regulate contractility in resistance-size cerebral artery smooth muscle, yet their molecular identity, subcellular location, and phenotype in this tissue remain unknown. Following rat resistance-size cerebral artery myocyte sarcoplasmic reticulum (SR) purification and incorporation into POPE-POPS-POPC (5:3:2; wt/wt) bilayers, unitary conductances of 110 +/- 8, 334 +/- 15, and 441 +/- 27 pS in symmetric 300 mM Cs(+) were usually detected. The most frequent (34/40 bilayers) conductance (334 pS) decreased to

SUBMITTER: Vaithianathan T 

PROVIDER: S-EPMC2928634 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature