Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2.
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ABSTRACT:
SUBMITTER: Foldy C
PROVIDER: S-EPMC2928876 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2.
Földy Csaba C Lee Sang-Hun SH Morgan Robert J RJ Soltesz Ivan I
Nature neuroscience 20100801 9
Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of h ...[more]
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