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Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2.


ABSTRACT: Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

SUBMITTER: Foldy C 

PROVIDER: S-EPMC2928876 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2.

Földy Csaba C   Lee Sang-Hun SH   Morgan Robert J RJ   Soltesz Ivan I  

Nature neuroscience 20100801 9


Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of h  ...[more]

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