Ontology highlight
ABSTRACT:
SUBMITTER: Zipfel PA
PROVIDER: S-EPMC2928877 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Zipfel P A PA Brady D C DC Kashatus D F DF Ancrile B D BD Tyler D S DS Counter C M CM
Oncogene 20100621 34
Up to one-third of human melanomas are characterized by an oncogenic mutation in the gene encoding the small guanosine triphosphatase (GTPase) NRAS. Ras proteins activate three primary classes of effectors, namely, Rafs, phosphatidyl-inositol-3-kinases (PI3Ks) and Ral guanine exchange factors (RalGEFs). In melanomas lacking NRAS mutations, the first two effectors can still be activated through an oncogenic BRAF mutation coupled with a loss of the PI3K negative regulator PTEN. This suggests that ...[more]