Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.
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ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC2928878 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
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Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.
Zhang Xiaofei X Bertaso Federica F Yoo Jong W JW Baumgärtel Karsten K Clancy Sinead M SM Lee Van V Cienfuegos Cynthia C Wilmot Carly C Avis Jacqueline J Hunyh Truc T Daguia Catherine C Schmedt Christian C Noebels Jeffrey J Jegla Timothy T
Nature neuroscience 20100801 9
We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2-/- (also known as Kcnh3-/-) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol. ...[more]
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