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ABSTRACT:
SUBMITTER: Alleti R
PROVIDER: S-EPMC2929268 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Alleti Ramesh R Rao Venkataramanarao V Xu Liping L Gillies Robert J RJ Mash Eugene A EA
The Journal of organic chemistry 20100901 17
A flexible molecular scaffold bearing varying numbers of terminal alkyne groups was synthesized in five steps from solanesol. R(CO)-MSH(4)-NH(2) ligands, which have a relatively low affinity for binding at the human melanocortin 4 receptor (hMC4R), were prepared by solid phase synthesis and were N-terminally acylated with 6-azidohexanoic acid. Multiple copies of the azide N(3)(CH(2))(5)(CO)-MSH(4)-NH(2) were attached to the alkyne-bearing, solanesol-derived molecular scaffold via the copper(I)-c ...[more]