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Development of a 2-aza-Cope-[3 + 2] dipolar cycloaddition strategy for the synthesis of quaternary proline scaffolds.


ABSTRACT: A one-pot multicomponent procedure for the synthesis of highly functionalized pyrrolidine rings through a domino 2-aza-Cope-[3 + 2] dipolar cycloaddition sequence has been demonstrated. This protocol was found to be both high-yielding and stereoselective for the endo cycloadduct.

SUBMITTER: McCormack MP 

PROVIDER: S-EPMC2929309 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Development of a 2-aza-Cope-[3 + 2] dipolar cycloaddition strategy for the synthesis of quaternary proline scaffolds.

McCormack Michael P MP   Shalumova Tamila T   Tanski Joseph M JM   Waters Stephen P SP  

Organic letters 20100901 17


A one-pot multicomponent procedure for the synthesis of highly functionalized pyrrolidine rings through a domino 2-aza-Cope-[3 + 2] dipolar cycloaddition sequence has been demonstrated. This protocol was found to be both high-yielding and stereoselective for the endo cycloadduct. ...[more]

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