Ontology highlight
ABSTRACT:
SUBMITTER: Clayton GM
PROVIDER: S-EPMC29294 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Clayton G M GM Peak-Chew S Y SY Evans R M RM Schwabe J W JW
Proceedings of the National Academy of Sciences of the United States of America 20010206 4
Ultraspiracle (USP) is the invertebrate homologue of the mammalian retinoid X receptor (RXR). RXR plays a uniquely important role in differentiation, development, and homeostasis through its ability to serve as a heterodimeric partner to many other nuclear receptors. RXR is able to influence the activity of its partner receptors through the action of the ligand 9-cis retinoic acid. In contrast to RXR, USP has no known high-affinity ligand and is thought to be a silent component in the heterodime ...[more]